Establishment of a bioindustry need-osteoarthritis rat model via surgery induction

Yi-Wei Lai 1, #, Pi-Hsin Chen 2, #, Ya-Ling Cyue 2, Ya-Peng Wang 2, Yu-Ying Fang 2, Shih-Yi Guo 2, Chia-Ying Lin 2, Keng-Chia Hsu 2, Tsung-Han Wu 2, Yan-Zhong Wu 2, Yu-Hsing Lin 1 and Shao-Wen Hung 2, 3, *

1 Department of Pet Healthcare, Yuanpei University of Medical Technology, Xiangshan, Hsinchu 300, Taiwan.
2 Division of Animal Industry, Animal Technology Research Center, Agricultural Technology Research Institute, Xiangshan, Hsinchu 300, Taiwan.
3 Department of Nursing, Yuanpei University of Medical Technology, Xiangshan, Hsinchu 300, Taiwan.
# Contributed equally to this work.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 27(01), 190–198.
Article DOI: 10.30574/gscbps.2024.27.1.0131
Publication history: 
Received on 04 March 2024; revised on 13 April 2024; accepted on 16 April 2024
 
Abstract: 
The degenerative arthritis has been a common knee joint disease in Taiwan. In mild cases of degenerative arthritis, it may just be a little uncomfortable to walk, but severe degenerative arthritis will cause difficulty in walking and even loss of basic mobility. The loss of articular cartilage in degenerative arthritis is irrecoverable. Currently, the degeneration of the knee joint can be easily divided into three levels based on its severity: primary, intermediate, and severe. The choice of treatments for degenerative arthritis will vary in according to different levels that is mainly divided into the non-surgical treatment and surgical treatment. Therefore, how to prevent knee joint degeneration is an important issue. In this study, anterior cruciate ligament transection (ACLT) combined with medial meniscectomy (MMx) surgery were used to established a rat model with degenerative arthritis. According to all data, we have successfully established a rat model with degenerative arthritis via ACLT-MMx surgery. We wish this model will applied on the research of the degenerative arthritis drugs and the design of therapeutic strategies for degenerative arthritis in the future.
 
Keywords: 
Anterior cruciate ligament transection; Degenerative arthritis; Medial meniscectomy; Osteoarthritis; Rat model; Surgery
 
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Copyright information: 
Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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