Prevalence of ESBL producing MDR E. coli and Klebsiellae pneumonae from clinical isolates of nosocomial hospital acquired infections
1 IIDRL lab Karachi University.
2 Dadabhoye institute of higher education.
3 Bolan university of medical and health sciences Quetta.
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 11(02), 175-181.
Article DOI: 10.30574/gscbps.2020.11.2.0131
Publication history:
Received on 06 May 2020; revised on 14 May 2020; accepted on 16 May 2020
Abstract:
The impact of nosocomial infections (NIs) is an important public health concern due to emergence of new MDR strains of pathogens and approximately 5 to 10% of hospitalized patients are affected by NIs. 90,000 deaths per year in United States only warrant investigation. This study was a hospital based cross sectional study to determine the ESBL producing MDR nosocomial infection and their control from Jun 1st2016 to Dec31st 2017. 500 patients were investigated all demographic data was collected from patients with a history of hospital admission for ≥ 2 days. In this study out of total 500 patients, (62%) patients were female and (38%) were males, 19% isolates were E.coli and 18% were K.pneumonae all were MDR along with other pathogens .most of strains were showing 55%-85% resistance for more than one antibiotics. PCR studies show that SHV (32%) and TEM (18%) genes were found in ESBLs producing organisms. Due to importance of ESBL producing organisms and difficult treatment of infections caused by these bacteria rapid identification of ESBL producing strains should be adopted in enterobacteraciae, infection control strategies are recommended to adopt and warrant investigation.
Keywords:
MDR multidrug resistant; ESBL Extended spectrum of Beta Lactamase; NIs nosocomial infections; Pathogens; PCR polymerase chain reaction
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
